The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad.

@article{Verdonk2014TheRS,
  title={The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad.},
  author={Koen Verdonk and Willy Visser and Anton H. van den Meiracker and A. H. Jan Danser},
  journal={Clinical science},
  year={2014},
  volume={126 8},
  pages={537-44}
}
Pregnancy demands major changes of the cardiovascular system, and this involves, among others, activation of the RAAS (renin-angiotensin-aldosterone system), allowing an aldosterone-dependent increase in volume. Remarkably, a relative resistance to the pressor response of AngII (angiotensin II) develops simultaneously to prevent the increase in blood pressure that would normally accompany RAAS activation. The increase in volume, the degree of RAAS activation and the diminished pressor response… CONTINUE READING