The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease.

@article{Brewster2004TheRS,
  title={The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease.},
  author={Ursula C. Brewster and Mark Anthony Perazella},
  journal={The American journal of medicine},
  year={2004},
  volume={116 4},
  pages={263-72}
}
The renin-angiotensin-aldosterone system regulates renal vasomotor activity, maintains optimal salt and water homeostasis, and controls tissue growth in the kidney. However, pathologic consequences can result from overactivity of this cascade, involving it in the pathophysiology of kidney disease. An activated renin-angiotensin-aldosterone system promotes both systemic and glomerular capillary hypertension, which can induce hemodynamic injury to the vascular endothelium and glomerulus. In… CONTINUE READING