The renin-angiotensin-aldosterone system and glucose homeostasis.

@article{Luther2011TheRS,
  title={The renin-angiotensin-aldosterone system and glucose homeostasis.},
  author={James M Luther and Nigel J. Brown},
  journal={Trends in pharmacological sciences},
  year={2011},
  volume={32 12},
  pages={
          734-9
        }
}
The renin-angiotensin-aldosterone system (RAAS) is inappropriately activated in obesity. In individuals at risk for diabetes, RAAS inhibition protects against kidney and heart disease, and also reduces the incidence of diabetes in large clinical trials. At a cellular level, angiotensin II (Ang II) and aldosterone induce insulin resistance by increasing oxidative stress and altering insulin signaling, leading to decreased glucose transport. Ang II also contributes to oxidative stress… CONTINUE READING
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Renin Angiotensin Aldosterone System (RAAS): its biology and drug targets for treating diabetic nephropathy.

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