The renal papilla is a niche for adult kidney stem cells.

  title={The renal papilla is a niche for adult kidney stem cells.},
  author={Juan A. Oliver and Omar Maarouf and Faisal Habib Cheema and Timothy P Martens and Qais Al-Awqati},
  journal={The Journal of clinical investigation},
  volume={114 6},
Many adult organs contain stem cells, which are pluripotent and are involved in organ maintenance and repair after injury. In situ, these cells often have a low cycling rate and locate in specialized regions (niches). To detect such cells in the kidney, we administered a pulse of the nucleotide bromodeoxyuridine (BrdU) to rat and mouse pups and, after a long (more than 2-month) chase, examined whether the kidney contained a population of low-cycling cells. We found that in the adult kidney… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 223 extracted citations


Publications referenced by this paper.
Showing 1-10 of 46 references

Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice

  • F Lin
  • J. Am. Soc. Nephrol
  • 2003
1 Excerpt

Identification of the haematopoietic stem cell niche and control of the niche size

  • J Zhang
  • Nature .
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…