The renal endothelium in diabetic nephropathy.

  title={The renal endothelium in diabetic nephropathy.},
  author={Theodoros Eleftheriadis and Georgia Antoniadi and Georgios G Pissas and Vassilios Liakopoulos and Ioannis Stefanidis},
  journal={Renal failure},
  volume={35 4},
Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetes mellitus is characterized by generalized endothelial dysfunction. However, recent data also emphasizes the role of local renal endothelium dysfunction in the pathogenesis of diabetic nephropathy. Hyperglycemia triggers a complex network of signal-transduction molecules, transcription factors, and mediators that culminate in endothelial dysfunction. In the glomerulus, vascular endothelial growth factor-A (VEGF… CONTINUE READING