The renal antifibrotic effects of angiotensin-converting enzyme inhibition involve bradykinin B2 receptor activation in angiotensin II-dependent hypertension.

@article{Seccia2006TheRA,
  title={The renal antifibrotic effects of angiotensin-converting enzyme inhibition involve bradykinin B2 receptor activation in angiotensin II-dependent hypertension.},
  author={Teresa Maria Seccia and Anna Sandra Belloni and Diego Guidolin and Daniele Sticchi and Gastone Giovanni Nussdorfer and Achille Cesare Pessina and Gian Paolo Rossi},
  journal={Journal of hypertension},
  year={2006},
  volume={24 7},
  pages={1419-27}
}
OBJECTIVE The renoprotective action of angiotensin I-converting enzyme inhibitors (ACE-Is) is well established, but the role played by bradykinin (BK) remains unclear. We therefore investigated whether an enhanced BK effect on B2 receptor subtype mediated the antifibrotic effect of ACE-Is and whether neutral endopeptidase (NEP) inhibition, which can blunt… CONTINUE READING