The renaissance of centrally acting antihypertensive drugs.

@article{Zwieten1999TheRO,
  title={The renaissance of centrally acting antihypertensive drugs.},
  author={Peter Adriaan van Zwieten},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  year={1999},
  volume={17 3},
  pages={S15-21}
}
Classic centrally acting antihypertensive drugs such as clonidine, guanfacine and alpha-methyl-dioxyphenylalanine (alpha-methyl-DOPA) (via its active metabolite alpha-methyl-noradrenaline) are assumed to induce peripheral sympathoinhibition and a reduction in (elevated) blood pressure as a result of the stimulation of alpha2-adrenoceptors in the pons… CONTINUE READING