The remarkable P450s: a historical overview of these versatile hemeprotein catalysts.

@article{Estabrook1996TheRP,
  title={The remarkable P450s: a historical overview of these versatile hemeprotein catalysts.},
  author={Ronald W. Estabrook},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1996},
  volume={10 2},
  pages={202-4}
}
The P450s are remarkable because there are so many of them and they do so many things. They are the products of a gene superfamily that includes representation from all phyla and many diverse species. At last count the cDNAs for more than 300 P450s had been cloned and se-quenced (1), and many have been expressed as functional recombinant enzymes in transformed yeast, bacteria, or mammalian cells. The P450s are claimed to catalyze more than 60 different types of chemical reactions , including… CONTINUE READING

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