• Corpus ID: 10040825

The relevance of the pharmacologic properties of a progestational agent to its clinical effects as a combination oral contraceptive.

@article{Upton1989TheRO,
  title={The relevance of the pharmacologic properties of a progestational agent to its clinical effects as a combination oral contraceptive.},
  author={Gertrude Virginia Upton and Alan Corbin},
  journal={The Yale Journal of Biology and Medicine},
  year={1989},
  volume={62},
  pages={445 - 457}
}
  • G. V. UptonA. Corbin
  • Published 1 September 1989
  • Medicine, Biology
  • The Yale Journal of Biology and Medicine
Levonorgestrel (LNg) is known for its marked progestational/contraceptive activity. As shown in animal experiments, however, high doses of LNg are required to elicit an androgenic response; in contrast, considerably lower doses of LNg are required for antiovulatory (contraceptive) action. Thus, a large dose separation exists between androgenic and contraceptive activity. When LNg is combined with an estrogen, as in the contraceptive formulations, the androgenic response is attenuated or negated… 

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