The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead.

@article{Gundacker2010TheRO,
  title={The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead.},
  author={Claudia Gundacker and Martin Gencik and Markus Hengstschlaeger},
  journal={Mutation research},
  year={2010},
  volume={705 2},
  pages={130-40}
}
The heavy metals mercury and lead are well-known and significant developmental neurotoxicants. This review summarizes the genetic factors that modify their toxicokinetics. Understanding toxicokinetics (uptake, biotransformation, distribution, and elimination processes) is a key precondition to understanding the individual health risks associated with exposure. We selected candidate susceptibility genes when evidence was available for (1) genes/proteins playing a significant role in mercury and… CONTINUE READING
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