The relevance of salt bridges for the stability of the influenza virus hemagglutinin.

@article{Rachakonda2007TheRO,
  title={The relevance of salt bridges for the stability of the influenza virus hemagglutinin.},
  author={Panduranga Sivaramakrishna Rachakonda and Michael Veit and Thomas Korte and Kai Ludwig and Christoph B{\"o}ttcher and Qiang Huang and Michael F. Schmidt and Andreas Herrmann},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 4},
  pages={995-1002}
}
Hemagglutinin (HA) of influenza virus undergoes an irreversible conformational change at acidic pH, mediating viral fusion with the host endosomal membrane. To unravel the molecular basis of the pH-dependent stability of HA, we demonstrate by mutagenesis of the prototype HA of virus strain X31 (H3 subtype) that salt bridges, especially a tetrad salt bridge within the monomers, are crucial for folding and stability of the trimeric ectodomain. This complex (tetrad) salt bridge is highly conserved… CONTINUE READING