The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia.

@article{Santamara2008TheRO,
  title={The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia.},
  author={Carlos M Santamar{\'i}a and Mar{\'i}a del Carmen Chill{\'o}n and Ram{\'o}n Garc{\'i}a-Sanz and Ana Balanzategui and Mar{\'i}a Eugenia Sarasquete and Miguel Alcoceba and Fernando Ramos and Teresa Bernal and Jos{\'e} Antonio Queiz{\'a}n and Mar{\'i}a Jes{\'u}s Pe{\~n}arrubia and Pilar Giraldo and Jes{\'u}s Fernando San Miguel and Marcos Gonzalez},
  journal={Haematologica},
  year={2008},
  volume={93 12},
  pages={1797-805}
}
BACKGROUND The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown. DESIGN AND METHODS We studied PRAME expression at diagnosis using real-time quantitative polymerase chain reaction in 125 patients with acute promyelocytic leukemia enrolled in the Spanish PETHEMA-96 (n=45) and PETHEMA-99 (n=80) clinical trials. In addition, PRAME expression was… CONTINUE READING

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