The relevance of large strains in functional tissue engineering of heart valves.

@article{Mol2003TheRO,
  title={The relevance of large strains in functional tissue engineering of heart valves.},
  author={A. Ajin Mol and Carlijn V C Bouten and Gregor Z{\"u}nd and Christina Irene G{\"u}nter and Jeroen F Visjager and Marko Ivan Turina and Frank T. P. Baaijens and Simon P Hoerstrup},
  journal={The Thoracic and cardiovascular surgeon},
  year={2003},
  volume={51 2},
  pages={78-83}
}
BACKGROUND Exposing the developing tissue to flow and pressure in a bioreactor has been shown to enhance tissue formation in tissue-engineered heart valves. Animal studies showed excellent functionality in these valves in the pulmonary position. However, they lack the mechanical strength for implantation in the high-pressure aortic position. Improving the in vitro conditioning protocol is an important step towards the use of these valves as aortic heart valve replacements. In this study, the… CONTINUE READING

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References

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Showing 1-10 of 22 references

The Relevance of .

A Mol
Thorac Cardiov Surg • 2003

Fluid shear stress

WJ Karlon, AA Lee, DA Graham, SD Cruz, A. Ratcliffe
provement of mechanical tissue properties. ASAIO J • 2002

Living, autologous pulmo

SP Hoerstrup, A Kadner, C Breymann
blasts. Thorac Cardiovasc Surg • 2001

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