The relevance of heat shock regulation in fungal pathogens of humans.

@article{Brown2010TheRO,
  title={The relevance of heat shock regulation in fungal pathogens of humans.},
  author={Alistair J P Brown and Michelle D. Leach and Susan M. Nicholls},
  journal={Virulence},
  year={2010},
  volume={1 4},
  pages={
          330-2
        }
}
Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C… CONTINUE READING
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