The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.

@article{Kurz2018TheRO,
  title={The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.},
  author={Jennifer Kurz and Robert Brunkhorst and Christian Foerch and Leonard Blum and Marina Henke and Laureen A Gabriel and Thomas Ulsh{\"o}fer and Nerea Ferreir{\'o}s and Michael J. Parnham and Gerd Geisslinger and Susanne Schiffmann},
  journal={Clinical science},
  year={2018},
  volume={132 17},
  pages={
          1963-1976
        }
}
Ceramide synthases (CerS) synthesize chain length specific ceramides (Cer), which mediate cellular processes in a chain length-dependent manner. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we observed that the genetic deletion of CerS2 suppresses EAE pathology by interaction with granulocyte-colony stimulating factor (G-CSF) signaling and CXC motif chemokine receptor 2 (CXCR2) expression, leading to impaired neutrophil migration. In the… 
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TLDR
Very long chain ceramides are important for G- CSF signaling and translocation of G-CSF-R into DRMs.
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TLDR
It is concluded that CerS6/C16‐Cer mediates anti‐inflammatory effects during the development of EAE and MS possibly by suppressing the migration and deactivation of neutrophils.
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TLDR
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TLDR
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TLDR
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