The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.

@article{Kurz2018TheRO,
  title={The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.},
  author={Jennifer Kurz and Robert Brunkhorst and Christian Foerch and Leonard Blum and Marina Henke and Laureen A Gabriel and Thomas Ulsh{\"o}fer and Nerea Ferreir{\'o}s and Michael J. Parnham and Gerd Geisslinger and Susanne Schiffmann},
  journal={Clinical science},
  year={2018},
  volume={132 17},
  pages={
          1963-1976
        }
}
Ceramide synthases (CerS) synthesize chain length specific ceramides (Cer), which mediate cellular processes in a chain length-dependent manner. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we observed that the genetic deletion of CerS2 suppresses EAE pathology by interaction with granulocyte-colony stimulating factor (G-CSF) signaling and CXC motif chemokine receptor 2 (CXCR2) expression, leading to impaired neutrophil migration. In the… 
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19 Citations
Background Citations
5
Methods Citations
1

19 Citations

Sphingolipid Players in Multiple Sclerosis: Their Influence on the Initiation and Course of the Disease
TLDR
Current evidence from studies on SLs (particularly gangliosides), which may shed new light upon processes underlying the MS background, are summarized and promising concepts are encouraged to encourage the further development of SL-based studies in the field of MS.
Ceramides as Novel Disease Biomarkers.
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
TLDR
The data indicate that detraction of the sphingolipid de novo synthesis in colon tissue might be an important trigger for UC and several lipids changed significantly in the blood, which might be used as biomarkers for disease control; however, diet-related variabilities need to be considered.
Advances in determining signaling mechanisms of ceramide and role in disease
TLDR
The role of ceramide in biological functions and disease are now better understood, with promise for development of therapeutic strategies to treat ceramide-regulated diseases.
Serum ceramide levels are altered in multiple sclerosis
TLDR
Ceramide levels are altered in PwMS and may be associated with retinal neurodegeneration and physical disability.
Ceramide signalling in inherited and multifactorial brain metabolic diseases
Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course
Distinctive sphingolipid patterns in chronic multiple sclerosis lesions
TLDR
The results suggest the existence of different SL metabolic pathways in the active versus inactive phase within progressive stages of MS, and suggest that C1P could be a new biomarker of the In-MS progressive phase, and its detection may help to develop future prognostic and therapeutic strategies for the disease.
Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells
TLDR
Data would indicate that gut-driven alterations in ceramide and mitochondrial function, particularly in glia and immune cells, underpin MS pathophysiology.
Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis.
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References

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TLDR
Very long chain ceramides are important for G- CSF signaling and translocation of G-CSF-R into DRMs.
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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