The release of leukotriene B4 during experimental inflammation.

  title={The release of leukotriene B4 during experimental inflammation.},
  author={P M Simmons and Javier A. Aldaz Salmon and Salvador Moncada},
  journal={Biochemical pharmacology},
  volume={32 8},
Leukotriene B4 (LTB4) has been detected by radioimmunoassay in inflammatory exudates obtained following the implantation of saline- or carrageenan-soaked polyester sponges in rats. The immunoreactive material was confirmed as LTB4 after extraction and purification by high pressure liquid chromatography. The peak concentration (6.9 +/- 0.5 ng/ml) was detected 6 hr after implantation of sponges soaked in 0.5% carrageenan; thereafter the level declined and was undetectable after 16-24 hr. The… CONTINUE READING
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