The release of biologically and immunologically reactive somatostatin from perifused hypothalamic fragments.

The purpose of this investigation was to 1) develop a hypothalamic perifusion system which would allow measurement of spontaneous basal somatostatin (SRIF) release, 2) compare the immunological and biological activities of released SRIF, and 3) study the effect of membrane depolarization, extracellular calcium, and several neurotransmitters on SRIF release… (More)