The relaxant action of nicorandil in guinea‐pig isolated trachealis

@article{Allen1986TheRA,
  title={The relaxant action of nicorandil in guinea‐pig isolated trachealis},
  author={Sandra L. Allen and R. W. Foster and G P Morgan and Roger C. Small},
  journal={British Journal of Pharmacology},
  year={1986},
  volume={87}
}
1 Nicorandil (1–1000 μmol 1–1) caused concentration‐dependent relaxation of guinea‐pig isolated trachealis. 2 Propranolol (1 μmol 1−1) did not modify the relaxant action of nicorandil but antagonized isoprenaline. 3 Among K+‐channel inhibitors tested, apamin (0.1 μmol 1−1) and procaine (5 mmol 1−1) did not modify the relaxant action of nicorandil. In contrast, tetraethylammonium (TEA, 8 mmol 1−1) caused five fold antagonism. 4 Trachealis exposed to K+‐rich (120 mmol 1−1) Krebs solution… 
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