The relatively selective cyclooxygenase‐2 inhibitor nimesulide: What's going on?

@article{Caiazzo2019TheRS,
  title={The relatively selective cyclooxygenase‐2 inhibitor nimesulide: What's going on?},
  author={Elisabetta Caiazzo and Armando Ialenti and Carla Cicala},
  journal={European Journal of Pharmacology},
  year={2019},
  volume={848},
  pages={105–111}
}

Figures and Tables from this paper

A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition

TLDR
In silico pharmacokinetic studies suggest that compounds 2b and 2c possess favorable drug‐likeness and oral bioavailability and may act as orally bioavailable anti‐inflammatory and antioxidant agents.

Mechanisms of Action of Nimesulide: Current Understanding

TLDR
The high bioavailability of nimesulide, effective pain relief, and a marked anti-inflammatory effect should be viewed as its advantages and make it the analgesic and anti- inflammatory medication of choice in clinical practice.

Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19

TLDR
Here it is suggested to include nimesulide in the list of drugs to be tested for the identification of co-adjuvants in the treatment of COVID-19, a global pandemic caused by the SARS-CoV-2 infection.

Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment

Background: Curcumin and resveratrol are two polyphenolic compounds extensively investigated for their medicinal effects on inflammatory signaling. However, there is a paucity of information on the

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

TLDR
The application of AgNMS@BCM was effective and safe in SSCC treatment in mice, and can be seen as a potential and safe agent for topic treatment of SSCC in humans.

Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?

TLDR
There is a need to improve nimesulide through its encapsulation by solid lipid nanoparticles to overcome problems related to the hepatotoxicity and bioavailability of the drug.

Inhibitory Effects of Bryophyllum pinnatum Leaf Extract on Inflammatory Biomarkers

TLDR
The study showed that B. pinnatum leaf extract possess a rich content of bioactive compounds which could be synthesized to produce new plantbased product to fight inflammatory disorders with fewer side effects.

Radiosynthesis and in Vivo and ex Vivo Evaluation of Isomeric [11C]methoxy Analogs of Nimesulide as Brain Cyclooxygenase-2-Targeted Imaging Agents.

TLDR
In vivo evaluation suggested that 11C-labeled para-methoxy nimesulide might correlate with COX-2 expression in the brain, but given its instability in vivo, [11C]1d seems unsuitable as a brain-COX- 2 radioimaging agent.

Evaluation of the potential environmental risk from the destination of medicines: an epidemiological and toxicological study.

TLDR
Results show that nimesulide may promote risk to aquatic organisms and to human health if it is discarded in an unsafe manner and teratogenic effects such as spinal cord defects, decreasing heartbeats, and increasing pericardial and yolk sac area in embryos were observed after exposure to nimesULide.

USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON PERIODONTAL THERAPY IN PATIENTS WITH COMORBID PATHOLOGY

TLDR
NSAIDs remain the most essential medications on etiotropic, pathogenetic and symptomatic therapy of dental disorders and will ensure the personified approach, efficacy and safety of NSAID use in patients.

References

SHOWING 1-10 OF 111 REFERENCES

Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug.

TLDR
The data suggests that gastrointestinal side effects of classic NSAIDs cannot be related to the COX-1 inhibition alone and suggest that nimesulide is an atypical NSAID, which is different from both non-selective and selective COx-2 inhibitors.

In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: An overview

  • J. Famaey
  • Biology, Medicine
    Inflammation Research
  • 1997
TLDR
Nimesulide is considered a relatively selective COX-2 inhibitor, as effective an analgesic and anti-inflammatory agent as classical NSAIDs, and a well-tolerated drug with few side-effects according to large-scale open studies and a global evaluation of a large number of controlled and non-controlled comparative trials.

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Abstract.This review summarizes the principal therapeutic responses to the preferential COX-2 NSAID, nimesulide, in treating musculo-skeletal joint symptoms and various acute and chronic pain

Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy

TLDR
How the new advancements in NSAIDs research has led to the development of a new class of NSAIDs that has far reaching implications for the treatment of disease is discussed.

Are there any Differences among Non-Steroidal Anti-Inflammatory Drugs? Focus on Nimesulide

TLDR
Due to its multifactorial mechanism as well as to rapid onset of the analgesic action, nimesulide represents an appealing therapeutic choice for the treatment of rheumatology patients.

Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

Prostaglandins have been shown to be involved in many different biological processes, under both normal and pathological conditions. As the key enzyme in the production of prostaglandins and

Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.

Anti-inflammatory and side effects of cyclooxygenase inhibitors.

TLDR
Induction of COX-2 by various growth factors, proinflammatory agents, endotoxins, mitogens, and tumor agents indicates that this isoform may have a role in induction of pathological processes, such as inflammation.

COX-2 inhibitors compared and contrasted

TLDR
The older drugs etodolac, nimesulide and meloxicam, made before COX-2 was discovered, are alsoCOX-1-sparing and have good GI safety and therapeutic activities.
...