The relative reactivity of deoxyribose and ribose: Did DNA come before RNA?


If it is assumed that there was a precursor to the ribose-phosphate backbone of RNA in the preRNA world (such as peptide nucleic acid), then the entry of various sugars into the genetic material may be related to the stability and non-enzymatic reactivity of the aldose. The rate of decomposition of 2-deoxyribose has been determined to be 1/3 that of ribose… (More)
DOI: 10.1007/BF02459842

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