The relative power of SNPs and haplotype as genetic markers for association tests.

@article{Bader2001TheRP,
  title={The relative power of SNPs and haplotype as genetic markers for association tests.},
  author={Joel S. Bader},
  journal={Pharmacogenomics},
  year={2001},
  volume={2 1},
  pages={11-24}
}
Identifying the polymorphisms that contribute to disease predisposition and drug response is a major goal of the post-genome era. Single nucleotide polymorphisms (SNPs) in disease-related genes are often used as candidates in the search for causative variations. Association tests based on haplotypes have also been suggested and, at times, have provided greater statistical power than tests based on the underlying SNPs. Here we review the statistical model traditionally used to describe… CONTINUE READING

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