The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro.

@article{Sieminski2004TheRM,
  title={The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro.},
  author={Alisha L. Sieminski and Robert P. Hebbel and Keith J. Gooch},
  journal={Experimental cell research},
  year={2004},
  volume={297 2},
  pages={
          574-84
        }
}
When suspended in collagen gels, endothelial cells elongate and form capillary-like networks containing lumens. Human blood outgrowth endothelial cells (HBOEC) suspended in relatively rigid 3 mg/ml floating collagen gels, formed in vivo-like, thin, branched multi-cellular structures with small, thick-walled lumens, while human umbilical vein endothelial cells (HUVEC) formed fewer multi-cellular structures, had a spread appearance, and had larger lumens. HBOEC exert more traction on collagen… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 110 extracted citations

Similar Papers

Loading similar papers…