The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.

@article{FernandezFunez1998TheRE,
  title={The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.},
  author={Pedro Fernandez-Funez and Chieh Hsiang Lu and Diego E Rincon-Limas and Antonio Garc{\'i}a-Bellido and Juan Botas},
  journal={The EMBO journal},
  year={1998},
  volume={17 23},
  pages={6846-53}
}
Dorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/Chip encodes a LIM-binding cofactor that controls Ap activity. Both lack and excess of dLdb/Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral transformations, generation of new wing margins, and wing outgrowths. These results indicate that the normal function of Ap in dorso… CONTINUE READING