The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-apoptotic effect of IFNalpha on pleomorphic sarcoma cells.

@article{Gazziola2005TheRE,
  title={The relative endogenous expression levels of the IFNAR2 isoforms influence the cytostatic and pro-apoptotic effect of IFNalpha on pleomorphic sarcoma cells.},
  author={Cinzia Gazziola and Nicoletta Cordani and Sonia Carta and Elisa De Lorenzo and Alfonso Colombatti and Roberto Perris},
  journal={International journal of oncology},
  year={2005},
  volume={26 1},
  pages={129-40}
}
Based on our previous studies where we found that IFNAR2-1, the short IFNalpha/beta receptor variant, was expressed in pleomorphic sarcoma cells, we decided to determine the relative levels of expression of IFNAR2.1 versus the longer form, named IFNAR2.2, in different pleomorphic sarcoma cells in relation to their response to interferon alpha treatment. When examining a panel of PS cells isolated from surgical specimens, we found that IFNAR2.1 prevailed in 6 out 7 lines analysed and that these… CONTINUE READING

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