The relationships between alkylation of haemoglobin and DNA in Fischer 344 rats exposed to [14C]ethylene oxide.

@article{Potter1989TheRB,
  title={The relationships between alkylation of haemoglobin and DNA in Fischer 344 rats exposed to [14C]ethylene oxide.},
  author={D Potter and Don Blair and Reginald Thorne Davies and William Patrick Watson and Alan S. Wright},
  journal={Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement},
  year={1989},
  volume={13},
  pages={
          254-7
        }
}
The quantification of products (adducts) of chemical reactions between geno-toxic chemicals and Hb may provide a basis for determining individual exposures to such agents and similarly the determination of Hb dose (in vivo) might be used to estimate the doses of ultimate genotoxic agents delivered to DNA (Ehrenberg et al 1974). The validation of this approach for its applicability to man relies on the study of the relationships in experimental species. Published data relating Hb- and tissue DNA… CONTINUE READING

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