The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full-length injury in the murine patellar tendon.

@article{Dyment2012TheRA,
  title={The relationships among spatiotemporal collagen gene expression, histology, and biomechanics following full-length injury in the murine patellar tendon.},
  author={Nathaniel A. Dyment and Namdar Kazemi and Lindsey E. Aschbacher-Smith and Nicolas J Barthelery and Keith Kenter and Cynthia Gooch and Jason T. Shearn and Christopher Wylie and David Butler},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2012},
  volume={30 1},
  pages={28-36}
}
Tendon injuries are major orthopedic problems that worsen as the population ages. Type-I (Col1) and type-II (Col2) collagens play important roles in tendon midsubstance and tendon-to-bone insertion healing, respectively. Using double transgenic mice, this study aims to spatiotemporally monitor Col1 and Col2 gene expression, histology, and biomechanics up to 8 weeks following a full-length patellar tendon injury. Gene expression and histology were analyzed weekly for up to 5 weeks while… CONTINUE READING

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Design and analysis of experiments, 7th ed

  • C. Montgomery
  • 2008
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