The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens

@article{Sahadevan2017TheRO,
  title={The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens},
  author={Mathavi Sahadevan and O. Lee and M. Muzzio and B. Phan and L. Jacobs and N. Khouri and J. Wang and Hong Hu and V. Stearns and R. Chatterton},
  journal={Biomarkers},
  year={2017},
  volume={22},
  pages={689 - 697}
}
Abstract Context: Clinical study of breast cancer patients in Chicago, IL, USA. Objective: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk. Methods: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. Results: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI… Expand

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