The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior.

@article{McBride1994TheRO,
  title={The relationship of platelet 5-HT2 receptor indices to major depressive disorder, personality traits, and suicidal behavior.},
  author={Patricia A. McBride and Richard P Brown and Michael DeMeo and John C. Keilp and Tom Mieczkowski and J. John Mann},
  journal={Biological psychiatry},
  year={1994},
  volume={35 5},
  pages={295-308}
}
Previous research has suggested that major depression and suicidal behavior may be associated with altered serotonin receptor function. In this study, platelet serotonin2 (5-HT2) receptor binding indices were measured in conjunction with serotonin-amplified platelet aggregation, a response mediated by the platelet 5-HT2 receptor complex, in depressed patients and normal controls. The magnitude of serotonin-amplified platelet aggregation was positively correlated with the number of platelet 5… CONTINUE READING
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