The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.

@article{Berkowitz1976TheRO,
  title={The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.},
  author={Bruce A. Berkowitz},
  journal={Clinical pharmacokinetics},
  year={1976},
  volume={1 3},
  pages={
          219-30
        }
}
This review illustrates current approaches to the study of the disposition in man of the strong analagesics morphine and methadone and the narcotic antagonist naloxone. Morphine administered orally is rapidly absorbed but equally rapidly metabolised to morphine glucuronide. This contributes to the diminished oral efficacy of morphine. Following intramuscular administration morphine is very rapidly absorbed. After intravenous injection, the serum levels of morphine during the first 10 minutes… CONTINUE READING

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