The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase.

@article{Cooper1996TheRO,
  title={The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase.},
  author={Chris E. Cooper and G R Lynagh and Kathryn P Hoyes and Robert C. Hider and Richard Cammack and John B. Porter},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 34},
  pages={20291-9}
}
The depletion of cellular iron can lead to the inhibition of ribonucleotide reductase, preventing new DNA synthesis and hence inhibiting cell proliferation. Electron paramagnetic resonance (EPR) spectroscopy has been used to examine simultaneously for the first time the relationship between chelation of intracellular iron and the rate of removal and… CONTINUE READING