The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats

@article{Need2005TheRO,
  title={The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats},
  author={A. Need and R. J. Davis and J. Alexander-Chacko and B. Eastwood and E. Chernet and L. Phebus and D. Sindelar and G. Nomikos},
  journal={Psychopharmacology},
  year={2005},
  volume={184},
  pages={26-35}
}
  • A. Need, R. J. Davis, +5 authors G. Nomikos
  • Published 2005
  • Medicine, Biology
  • Psychopharmacology
  • RationaleCannabinoid type 1 (CB1) receptor antagonists are reportedly effective in reducing food intake both preclinically and clinically. This may be due in part to their effects on monoamine release in the brain. The level of central CB1 receptor occupancy underlying these neurobiological effects is unclear.ObjectivesWe explored the relationship between in vivo CB1 receptor occupancy in the frontal cortex and changes in both monoamine release in the medial prefrontal cortex (mPFC) and feeding… CONTINUE READING
    49 Citations
    Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats
    • 4
    Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
    • 12
    MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice
    • 7
    • Highly Influenced
    Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model
    • 20

    References

    SHOWING 1-10 OF 45 REFERENCES
    The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
    • 262
    A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding
    • 471
    • PDF
    CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents
    • 200
    Fluoxetine increases norepinephrine release in rat hypothalamus as measured by tissue levels of MHPG-SO4 and microdialysis in conscious rats
    • 39
    Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.
    • 529
    • PDF
    Novel, not adenylyl cyclase-coupled cannabinoid binding site in cerebellum of mice.
    • 78
    Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the antagonist/inverse agonist AM281
    • 60
    • Highly Influential