The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria.

@article{Wood1961TheRO,
  title={The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria.},
  author={R. C. Wood and R. Ferone and G. Hitchings},
  journal={Biochemical pharmacology},
  year={1961},
  volume={6},
  pages={
          113-24
        }
}
Abstract As a possible means for determining the influence of cellular permeability on the action of the antifolic acid drugs in bacteria, a comparison has been made of their effects on whole cells and on cell-free extracts of several species. The parameters examined were inhibition of growth, inhibition of folinic acid synthesis in whole cells and inhibition of folinic acid synthesis in cell-free extracts. In Streptococcus faecalis the concentrations of amethopterin and pyrimethamine required… Expand
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