The relationship of acute mesodermal cell death to the teratogenic effects of 7-OHM-12-MBA in the foetal rat.


WE recently described the embryopathic effects of 7-hydroxymethyl12methylbenz(a)anthracene (7-OHM12MBA) (Currie et al., 1970), one of the principal metabolites of 7,1 2-dimethylbenz(a)anthracene (DMBA) (Boyland and Sims, 1965), in the Sprague-Dawley rat. A single intravenous injection of 7-OHM-12-MBA (2.5 mg/100 g maternal body weight) on Day 11-14 of… (More)
DOI: 10.1038/bjc.1972.67


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