The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

@article{Goodin1999TheRO,
  title={The relationship of MS to physical trauma and psychological stress: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.},
  author={Douglas S. Goodin and George Cornell Ebers and Kenneth P. Johnson and Marelis Rodriguez and William A. Sibley and Jerry S. Wolinsky},
  journal={Neurology},
  year={1999},
  volume={52 9},
  pages={1737-45}
}
Overview. The idea that physical trauma or psychological stress might be involved in either the causation or exacerbation of MS dates back to the time of Charcot and the earliest descriptions of the illness. In 1897, for example, Mendel reported four cases of MS that began within a year of severe skull or spinal injury. In 1901, Klausner found antecedent trauma in 24 of 126 (19.0%) new-onset cases of MS. Similarly, in 1902, Hoffman reported a series of 100 new-onset MS patients, of whom 8 (8… CONTINUE READING
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