The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals
@article{Francis1981TheRO, title={The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals}, author={A. A. Francis and W. H. Lee and J. Regan}, journal={Mechanisms of Ageing and Development}, year={1981}, volume={16}, pages={181-189} }
Physical and chemical agents present in the environment can potentially damage mammalian DNA. Such damage is known in some cases to be repaired by the process of DNA excision repair. This process has been extensively studied utilizing the repair of ultraviolet irradiation damage as a model system. In this study we have used this system and the 5-bromodeoxyuridine photolysis assay to measure DNA excision repair in cells derived from 21 mammalian species. We have attempted to relate the DNA… Expand
Topics from this paper
99 Citations
Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts.
- Biology, Medicine
- Mutation research
- 1984
- 52
Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan
- Biology, Medicine
- AGE
- 2011
- 19
- Highly Influenced
Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span
- Biology, Medicine
- Mechanisms of Ageing and Development
- 1984
- 80
There is substantial agreement among interspecies estimates of DNA repair activity
- Biology, Medicine
- Mechanisms of Ageing and Development
- 1996
- 116
Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals
- Biology, Medicine
- GeroScience
- 2020
Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.
- Biology, Medicine
- The journals of gerontology. Series A, Biological sciences and medical sciences
- 2008
- 28
- PDF
References
SHOWING 1-10 OF 16 REFERENCES
Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyurea.
- Biology, Medicine
- Biochimica et biophysica acta
- 1979
- 107
Applicability of Bacterial Models of DNA Repair and Recovery to UV-Irradiated Mammalian Cells
- Biology
- 1978
- 15
Normal and defective repair of damaged DNA in human cells: a sensitive assay utilizing the photolysis of bromodeoxyuridine.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1971
- 187
- PDF
Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.
- Biology, Medicine
- Cancer research
- 1974
- 413
DNA repair in a short- and a long-lived rodent species.
- Biology, Medicine
- Journal of gerontology
- 1979
- 83
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1974
- 707
- PDF
Enhancement of repair replication in mammalian cells by hydroxyurea.
- Biology, Medicine
- Mutation research
- 1978
- 62