The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals

@article{Francis1981TheRO,
  title={The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals},
  author={Andrew A. Francis and W. H. Lee and James D. Regan},
  journal={Mechanisms of Ageing and Development},
  year={1981},
  volume={16},
  pages={181-189}
}
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99 Citations
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99 Citations

Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts.
Interspecies Differences in the Removal of DNA Adducts
TLDR
It is apparent that significant differences in DNA repair exist among species, within species, and between organs, and it is now a reasonable speculation that such differences may, in part, account for differences in organ susceptibility and risk per cell per unit time for spontaneous malignant transformation observed between species.
Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan
TLDR
Testing whether an enhancement of BER enzyme activities has occurred concomitantly with the evolution of increased maximum lifespan (MLSP) found nucleotide incorporation and oligonucleotide ligation activities appeared to be primarily (and negatively) correlated with species body mass.
Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span
Age and Species Specific Variation in DNA Excision Repair in Cultured Skin Fibroblasts
TLDR
The relevance of one form of DNA repair, excision repair, to the aging process is discussed on the basis of the state of the excison repair pathway in rat fibroblasts during in vitro and in vivo aging and the differences in the excision process between normal human and rat fibrablasts.
DNA damage and repair during cellular aging.
  • S. Rattan
  • Biology
    International review of cytology
  • 1989
There is substantial agreement among interspecies estimates of DNA repair activity
Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals
TLDR
The higher mitochondrial BER of long-lived mammals contributes to their superior longevity, agrees with the updated version of the mitochondrial free radical theory of aging, and indicates the special relevance of mitochondria and mitROS for aging.
Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.
TLDR
It is reported that cells from Snell dwarf mice recover more rapidly than controls from the inhibition of RNA synthesis induced by UV damage, suggesting enhanced repair of the actively transcribing genes in dwarf-derived cells.
DNA Damage Induced by Ultraviolet Radiation
TLDR
Understanding of the biochemical foundation of the cytotoxic, mutagenic, and carcinogenic effects of UVR has greatly increased and the adverse effects of global stratospheric deozonation can be mitigated by the development and application of basic photobiological research.
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References

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DNA repair in bacteria and mammalian cells.
Since bacterial excision repair was last reviewed not only has the understanding of previously recognized mechanisms increased, but new mechanisms have been described which have broadened the concept…
Inhibition of DNA repair in ultraviolet-irradiated human cells by hydroxyurea.
Applicability of Bacterial Models of DNA Repair and Recovery to UV-Irradiated Mammalian Cells
Normal and defective repair of damaged DNA in human cells: a sensitive assay utilizing the photolysis of bromodeoxyuridine.
  • J. Regan, R. Setlow, R. Ley
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1971
TLDR
The quantitative aspects of this assay for repair and its sensitivity should make it applicable to the study of repair induced by agents other than UV radiation.
Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.
Summary DNA repair in human cells, as assayed by the photolysis of 5-bromodeoxyuridine incorporated during repair, takes one of two limiting forms, depending on the nature of the original insult to…
DNA repair in a short- and a long-lived rodent species.
TLDR
A determination of patch size by bromouracil photolysis following ultraviolet irradiation revealed that the patch sizes were the same for the two species, and that the number of repaired sites was 2.2 times greater for Peromyscus than for Mus, in agreement with the ratio found by measurement of unscheduled DNAmore synthesis.
ABSENCE OF CORRELATION BETWEEN DNA REPAIR IN ULTRAVIOLET IRRADIATED MAMMALIAN CELLS AND LIFE SPAN OF THE DONOR SPECIES
TLDR
There was no correlation between repair potentials and life span, denying the presence of the correlation suggested by Hart and Setlow on 7 species.
The inhibition of repair in UV irradiated human cells.
Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.
  • R. Hart, R. Setlow
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1974
TLDR
The ability of fibroblasts to perform unscheduled DNA synthesis after UV irradiation was measured radioautographically for seven species at several times after several UV fluences and the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species.
Enhancement of repair replication in mammalian cells by hydroxyurea.
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