The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals
@article{Francis1981TheRO, title={The relationship of DNA excision repair of ultraviolet-induced lesions to the maximum life span of mammals}, author={Andrew A. Francis and W. H. Lee and James D. Regan}, journal={Mechanisms of Ageing and Development}, year={1981}, volume={16}, pages={181-189} }
99 Citations
Kinetics of ultraviolet induced DNA excision repair in rat and human fibroblasts.
- BiologyMutation research
- 1984
Interspecies Differences in the Removal of DNA Adducts
- Biology
- 1983
It is apparent that significant differences in DNA repair exist among species, within species, and between organs, and it is now a reasonable speculation that such differences may, in part, account for differences in organ susceptibility and risk per cell per unit time for spontaneous malignant transformation observed between species.
Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan
- BiologyAGE
- 2011
Testing whether an enhancement of BER enzyme activities has occurred concomitantly with the evolution of increased maximum lifespan (MLSP) found nucleotide incorporation and oligonucleotide ligation activities appeared to be primarily (and negatively) correlated with species body mass.
Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span
- Biology, MedicineMechanisms of Ageing and Development
- 1984
Age and Species Specific Variation in DNA Excision Repair in Cultured Skin Fibroblasts
- Biology, Medicine
- 1986
The relevance of one form of DNA repair, excision repair, to the aging process is discussed on the basis of the state of the excison repair pathway in rat fibroblasts during in vitro and in vivo aging and the differences in the excision process between normal human and rat fibrablasts.
There is substantial agreement among interspecies estimates of DNA repair activity
- BiologyMechanisms of Ageing and Development
- 1996
Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals
- BiologyGeroScience
- 2020
The higher mitochondrial BER of long-lived mammals contributes to their superior longevity, agrees with the updated version of the mitochondrial free radical theory of aging, and indicates the special relevance of mitochondria and mitROS for aging.
Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.
- BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
- 2008
It is reported that cells from Snell dwarf mice recover more rapidly than controls from the inhibition of RNA synthesis induced by UV damage, suggesting enhanced repair of the actively transcribing genes in dwarf-derived cells.
DNA Damage Induced by Ultraviolet Radiation
- Biology
- 2006
Understanding of the biochemical foundation of the cytotoxic, mutagenic, and carcinogenic effects of UVR has greatly increased and the adverse effects of global stratospheric deozonation can be mitigated by the development and application of basic photobiological research.
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Since bacterial excision repair was last reviewed not only has the understanding of previously recognized mechanisms increased, but new mechanisms have been described which have broadened the concept…
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The quantitative aspects of this assay for repair and its sensitivity should make it applicable to the study of repair induced by agents other than UV radiation.
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The ability of fibroblasts to perform unscheduled DNA synthesis after UV irradiation was measured radioautographically for seven species at several times after several UV fluences and the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species.