The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

@article{Andrew1993TheRB,
  title={The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease},
  author={Susan E. Andrew and Yigal Paul Goldberg and B Kremer and H{\aa}kan Telenius and Jane Theilmann and Shelin Adam and Elizabeth Starr and Ferdinando Squitieri and Biaoyang Lin and Michael A. Kalchman and Rona K Graham and Michael R. Hayden},
  journal={Nature Genetics},
  year={1993},
  volume={4},
  pages={398-403}
}
Huntington's disease (HD) is associated with the expansion of a CAG trinucleotide repeat in a novel gene. We have assessed 360 HD individuals from 259 unrelated families and found a highly significant correlation (r = 0.70, p = 10−7) between the age of onset and the repeat length, which accounts for approximately 50% of the variation in the age of onset. Significant associations were also found between repeat length and age of death and onset of other clinical features. Sib pair and parent… 
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TLDR
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TLDR
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TLDR
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