The relationship between total kidney cyclosporin A concentrations, trough drug levels and renal function in the rat following withdrawal of treatment.

@article{Mead1994TheRB,
  title={The relationship between total kidney cyclosporin A concentrations, trough drug levels and renal function in the rat following withdrawal of treatment.},
  author={Jerry Mead and Paul A. J. Brown and Paul H. Whiting},
  journal={Human & experimental toxicology},
  year={1994},
  volume={13 7},
  pages={506-11}
}
Groups of 6 male rats received cyclosporin A (CsA: 20 mg kg-1 day-1) by gavage for either 4, 7, 10 or 14 days and were sacrificed 24 hours later. CsA nephrotoxicity was characterised functionally by decreased creatinine clearance rates and increased enzymuria. A significant correlation (r2 = 0.980; P < 0.01) was observed between the CsA concentration in… CONTINUE READING