The relationship between the nucleolus and cancer: Current evidence and emerging paradigms.

@article{Oroli2016TheRB,
  title={The relationship between the nucleolus and cancer: Current evidence and emerging paradigms.},
  author={Ines Or{\vs}oli{\'c} and Deana Jurada and Nick Pullen and Moshe Oren and Aristides G. Eliopoulos and Sini{\vs}a Volarevi{\'c}},
  journal={Seminars in cancer biology},
  year={2016},
  volume={37-38},
  pages={36-50}
}
The nucleolus is the most prominent nuclear substructure assigned to produce ribosomes; molecular machines that are responsible for carrying out protein synthesis. To meet the increased demand for proteins during cell growth and proliferation the cell must increase protein synthetic capacity by upregulating ribosome biogenesis. While larger nucleolar size and number have been recognized as hallmark features of many tumor types, recent evidence has suggested that, in addition to overproduction… CONTINUE READING
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