The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease.

@article{Lawrence1998TheRB,
  title={The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease.},
  author={A. D. Lawrence and Robert A Weeks and David J. Brooks and Thomasin C. Andrews and L Andrew Watkins and Anita E. Harding and Trevor W. Robbins and Barbara J. Sahakian},
  journal={Brain : a journal of neurology},
  year={1998},
  volume={121 ( Pt 7)},
  pages={1343-55}
}
Seventeen individuals at risk for Huntington's disease and five symptomatic patients, who had previously undergone [11C]SCH23390 and [11C]raclopride PET to assess in vivo levels of striatal dopamine D1 and D2 receptor binding, had neuropsychological assessment on a series of tests known to be sensitive to symptomatic Huntington's disease, including tests of verbal fluency, memory, attention and planning. Compared with age- and IQ-matched healthy volunteers, clinically symptomatic carriers of… CONTINUE READING
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