The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls

  title={The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls},
  author={Traci A. Stuve and Lee Friedman and John A. Jesberger and Grover C. Gilmore and Milton E. Strauss and Herbert Y. Meltzer},
  journal={Psychological Medicine},
  pages={143 - 152}
Background. In this study, we tested the hypothesis that low smooth pursuit gain in schizophrenia is related to an abnormality in motion perception. Methods. The subjects were 19 schizophrenics treated with clozapine and 19 controls. In addition to smooth pursuit and motion perception paradigms, sustained attention was also assessed using a continuous performance task (CPT). Results. In the patient group, there was a statistically significant negative correlation between smooth pursuit gain and… 

Motion perception in schizophrenia.

The discrimination of small velocity differences is impaired in a subgroup of patients with schizophrenia, and both motion signals and the brain regions responsible for processing motion signals are implicated in the generation of smooth pursuit.

Response to unexpected target changes during sustained visual tracking in schizophrenic patients

Findings of superior performance by schizophrenic patients are interesting because they circumvent confounds of generalized deficits and provide further evidence of specific deficit in the predictive pursuit mechanism and over-reliance on retinal error signals to maintain pursuit in schizophrenia.

Smooth-pursuit eye movement and directional motion-contrast sensitivity in schizophrenia

A relationship was found between a significant reduction in directional motion-contrast sensitivity and significantly reduced smooth-pursuit eye movement in the negative-symptom group and serves to further cleave the distinction between positive and negative symptoms in schizophrenia.

Efference Copy Failure during Smooth Pursuit Eye Movements in Schizophrenia

Although patients' pursuit showed normal improvement with longer duration, their prediction performance failed to benefit from duration increases, and dissociation indicates relatively intact early visual motion processing, but a failure to use efference copy information.

Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia.

Deficient processing of velocity information seems to be one component that contributes to a dysfunction in the initiation and maintenance of smooth pursuit in schizophrenia.

Neural mechanisms of smooth pursuit eye movements in schizotypy

These posterior activation differences are compatible with evidence of motion processing deficits from the schizophrenia literature and, therefore, suggest overlap between schizotypy and schizophrenia both on cognitive‐perceptual and neurophysiological levels.

Impaired detection of visual motion in schizophrenia patients

  • C. Li
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2002

Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia.

It is suggested that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.



The relationship between smooth pursuit eye movement impairment and psychological measures of psychopathology

In the neuropsychological area, measures of attention control and perceptual-motor dysfunction for the total sample, and perceptual problems and general intellectual decrements for the poor eyetrackers were significantly related to poor performance, but there was no relationship between measures of affective dysfunction andpoor eyetracking.

Recent studies of psychophysiology in schizophrenia.

  • P. Holzman
  • Psychology, Medicine
    Schizophrenia bulletin
  • 1987
Eye movement dysfunctions have been shown to be reliably associated with schizophrenia as a trait, suggesting disorders of nonvoluntary attention in association with those brain areas involved in

A selective impairment of motion perception following lesions of the middle temporal visual area (MT)

  • W. NewsomeEB Pare
  • Psychology, Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
The results indicate that neural activity in MT contributes selectively to the perception of motion.

Eye-tracking performance and engagement of attention.

The results indicate that poor eye-tracking can be improved by facilitating attentional effort; it is suggested that the number-reading maneuver improved tracking by providing extra feedback cues.