The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients

@article{Minassian2007TheRB,
  title={The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients},
  author={Arpi Minassian and David Feifel and William Perry},
  journal={Schizophrenia Research},
  year={2007},
  volume={89},
  pages={225-231}
}
It has been suggested that sensorimotor gating deficits as indexed by prepulse inhibition (PPI) of the acoustic startle reflex represent an endophenotypic marker of psychotic conditions such as schizophrenia (SCZ). This hypothesis has been questioned as several studies have found that PPI levels change with improvement in symptoms and are responsive to medications. We tested PPI in a sample of acutely decompensated schizophrenia patients who were re-tested after 2 weeks of hospital treatment… CONTINUE READING

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