The relationship between plasma t-PA and PAI-1 levels is dependent on epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms.

@article{Moore2002TheRB,
  title={The relationship between plasma t-PA and PAI-1 levels is dependent on epistatic effects of the ACE I/D and PAI-1 4G/5G polymorphisms.},
  author={Jason H. Moore and Mark Smolkin and Jennifer M. Lamb and Nancy J. Brown and Douglas E. Vaughan},
  journal={Clinical genetics},
  year={2002},
  volume={62 1},
  pages={53-9}
}
Thrombus formation and degradation is partly due to a complex interplay between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1). There is accumulating evidence that plasma levels of t-PA and PAI-1 may be influenced by an interaction between the fibrinolytic and renin-angiotensin systems. The goal of this study was to conduct an exploratory data analysis to determine whether there is evidence that the relationship (i.e. correlation) between plasma t-PA and… CONTINUE READING

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