The relationship between permeant size and permeability in lipid bilayer membranes

  title={The relationship between permeant size and permeability in lipid bilayer membranes},
  author={Tian-xiang Xiang and Bradley D. Anderson},
  journal={The Journal of Membrane Biology},
Permeability coefficients (Pm) across planar egg lecithin/decane bilayers and bulk hydrocarbon/water partition coefficients (Kw→hc) have been measured for 24 solutes with molecular volumes, V, varying by a factor of 22 and Pm values varying by a factor of 107 to explore the chemical nature of the bilayer barrier and the effects of permeant size on permeability. A proper bulk solvent which correctly mimics the microenvironment of the barrier domain was sought. Changes in Pm/Kw→hc were then… 

Permeability of fluid-phase phospholipid bilayers: assessment and useful correlations for permeability screening and other applications.

The results serve as a starting point for estimating passive permeability of cell membranes to nonionized solutes as a function of temperature and cholesterol content of the membrane.

Phospholipid surface density determines the partitioning and permeability of acetic acid in DMPC:cholesterol bilayers

The results suggest that dehydration, previously considered to be a dominant component, is a minor factor in determining Ea, and chain ordering is a major determinant for molecular partitioning and transport across lipid bilayers, regardless of whether it is varied by lipid composition or temperature.

Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer

Functional group contributions to transport across egg lecithin bilayers appear to be independent of the compound to which they are attached, even though the thickness of the barrier domain in lipid bilayers is approximately the same as the extended length of the permeant.

Structural Determinants of Water Permeability through the Lipid Membrane

It is found that water permeability correlates most strongly with the area/lipid and is poorly correlated with bilayer thickness and other previously determined structural and mechanical properties of these single component bilayers.

Structural Determinants of Drug Partitioning in n-Hexadecane/Water System

Observations indicate that the headgroups stratum, albeit well hydrated, does not have solvation characteristics similar to water and is also poorly described by the O/W partition characteristics.

Transfer of Small Molecules Across Membrane-Mimetic Interfaces

The presented thesis investigates the transfer of drug molecules across interfaces that mimic biological membrane barriers in a novel artificial membrane permeation assay configuration using an in situ time-dependent approach and reproducible rotation of the membrane.

A theoretical analysis of permeation of small hydrophobic solutes across the stratum corneum based on Scaled Particle Theory.

A mathematical model is developed that can predict skin permeability to small (MW < 500 Da), hydrophobic solutes based on the fundamental transport properties of skin lipid bilayers and molecular properties of the solute.

Permeability of drugs and hormones through a lipid bilayer: insights from dual-resolution molecular dynamics†

The unassisted permeation process of β-blocker drugs and steroid hormones through a lipid membrane is simulated by a novel dual-resolution molecular dynamics approach, and the proposed permeation model highlights and addresses potentially problematic aspects of the standard solubility-diffusion theory.

Simple Predictive Models of Passive Membrane Permeability Incorporating Size-Dependent Membrane-Water Partition

Investigation of the relationship between passive permeability and molecular size, in the context of solubility-diffusion theory, using a diverse compound set with molecular weights, suggests that these measurements are not size selective, a possible reason for their sometimes weak correlation with cell-based permeability.



Transport methods for probing the barrier domain of lipid bilayer membranes.

Monocarboxylic acid permeation through lipid bilayer membranes

The exceptionally high permeability of formic acid and the high correlation of the other permeabilities to the hexadecane/water partition coefficient is a pattern that conforms with other nonelectrolyte permeabilities through bilayers, similar to other homologous solutes in other membrane systems.

Permeability of small nonelectrolytes through lipid bilayer membranes

Diffusion of small nonelectrolytes through planar lipid bilayer membranes was examined by correlating the permeability coefficients of 22 solutes with their partition coefficients between water and four organic solvents, and the molecular volume dependence of solute permeability suggests that the membrane barrier behaves more like a polymer than a liquid hydrocarbon.

Diffusion of lonizable Solutes Across Planar Lipid Bilayer Membranes: Boundary-Layer pH Gradients and the Effect of Buffers

A theoretical model has been developed to describe the diffusion of both permeant and buffer species and predicted that membrane-permeable buffers significantly reduce boundary layer pH gradients through a feedback effect due to buffer cotransport.

Weak acid permeability through lipid bilayer membranes. Role of chemical reactions in the unstirred layer

The premeabilities of planar lipid bilayer membranes to butyric and formic acids were measured by tracer and pH electrode techniques to establish criteria for the applicability of each method and to resolve a discrepancy between previously published permeabilities determined using the different techniques.

Water and nonelectrolyte permeability of lipid bilayer membranes

The general conclusion of this study is that H2O and nonelectrolytes cross lipid bilayer membranes by a solubility- diffusion mechanism, and that the bilayer interior is much more like an oil than a rubber-like polymer.

Solute structure-permeability relationships in human stratum corneum.

Although uptake into human stratum corneum was relatively insensitive to solute lipophilicity, reflecting the predominant role of proteins in the uptake, permeability coefficients were found to be more sensitive to lipophilicities, suggesting that transport is by a lipid pathway.

Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene.

  • S. White
  • Biology, Chemistry
    Biophysical journal
  • 1978