The relationship between permeant size and permeability in lipid bilayer membranes

@article{Xiang2004TheRB,
  title={The relationship between permeant size and permeability in lipid bilayer membranes},
  author={Tian-xiang Xiang and Bradley D. Anderson},
  journal={The Journal of Membrane Biology},
  year={2004},
  volume={140},
  pages={111-122}
}
Permeability coefficients (Pm) across planar egg lecithin/decane bilayers and bulk hydrocarbon/water partition coefficients (Kw→hc) have been measured for 24 solutes with molecular volumes, V, varying by a factor of 22 and Pm values varying by a factor of 107 to explore the chemical nature of the bilayer barrier and the effects of permeant size on permeability. A proper bulk solvent which correctly mimics the microenvironment of the barrier domain was sought. Changes in Pm/Kw→hc were then… 

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