The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis

@article{Lu2018TheRB,
  title={The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis},
  author={Feng-Bin Lu and En-de Hu and Lanman Xu and Lu Chen and Jin-Lu Wu and Hui Li and Da-zhi Chen and Yong-Ping Chen},
  journal={Expert Review of Gastroenterology \& Hepatology},
  year={2018},
  volume={12},
  pages={491 - 502}
}
ABSTRACT Introduction: A number of researches have explored the association between obesity and nonalcoholic fatty liver disease (NAFLD) liver function, histopathology, complications, genetic factors and prognosis, but the results were conflicting and inconclusive. Areas covered: In this meta-analysis, the liver function, histopathology, metabolic complications, patatin-like phospholipase domain-containing protein 3 (PNPLA3) genetic polymorphism and prognosis were compared between non-obese and… 
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Non alcoholic fatty liver disease and risk of incident diabetes in subjects who are not obese.
Insulin resistance associates with hepatic lobular inflammation in subjects with obesity
TLDR
A major contributing histological component of NAFLD to the relation betweenNAFLD severity and IR seems to be the grade of hepatic lobular inflammation, which might be of importance in controlling obesity-related metabolic disturbances.
Health benefits of Mediterranean diet in nonalcoholic fatty liver disease
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CHDH-PNPLA3 Gene–Gene Interactions Predict Insulin Resistance in Children with Obesity
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The interaction between genotypes in CHDH and PNPLA3 genes, modulated by choline and alanine aminotransferase levels, predicted insulin-resistance status in children with obesity.
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