The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis

  title={The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis},
  author={Feng-Bin Lu and En-de Hu and Lanman Xu and Lu Chen and Jin-Lu Wu and Hui Li and Da-Zhi Chen and Yong-Ping Chen},
  journal={Expert Review of Gastroenterology \& Hepatology},
  pages={491 - 502}
ABSTRACT Introduction: A number of researches have explored the association between obesity and nonalcoholic fatty liver disease (NAFLD) liver function, histopathology, complications, genetic factors and prognosis, but the results were conflicting and inconclusive. Areas covered: In this meta-analysis, the liver function, histopathology, metabolic complications, patatin-like phospholipase domain-containing protein 3 (PNPLA3) genetic polymorphism and prognosis were compared between non-obese and… 

Association between obesity profile and non-alcoholic fatty liver by race/ethnicity

Healthcare providers should pay more attention to care for those who are part of the metabolically healthy overweight or obese group especially among the Mexican-American population.

Relationship between total testosterone, sex hormone–binding globulin levels and the severity of non-alcoholic fatty liver disease in males: a meta-analysis

The present meta-analysis shows that lower TT is associated with the severity ofNAFLD in males, while the relationship between SHBG and severity of NAFLD is still to be further verified.

Assessment of the association between body composition and risk of non-alcoholic fatty liver

Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level, and the total fat percent had the highest AUC to predict the risk ofNAFLD.

A review of non‐alcoholic fatty liver disease in non‐obese and lean individuals

There is not enough evidence on the treatment of NAFLD in non‐obese patients, the standard approach is to advise altering one's lifestyle in order to diminish visceral adiposity, so dietary modification, weight loss, and increased physical activity are highly recommended.

Association between serum ferritin and non-alcoholic fatty liver disease among middle-aged and elderly Chinese with normal weight.

SF was positively associated with the risk of NAFLD and elevated ALT among normal-weight Chinese adults and ROC analysis suggested that SF may serve as an indicator of predictingNAFLD.

Association of leukocyte telomere length with non-alcoholic fatty liver disease in patients with type 2 diabetes

T2DM patients with NAFLD had a significantly longer leukocyte telomere length (LTL), which was especially evident in the early stage of T2DM, indicating that longer LTL may be used as a biomarker forNAFLD in T1DM patients.

The Epidemiology, Risk Profiling and Diagnostic Challenges of Nonalcoholic Fatty Liver Disease

A case can be made for screening of NAFLD to facilitate early diagnosis and to prevent the hepatic and extra-hepatic complications in high risk sub-populations with morbid obesity, diabetes, and other metabolic risk factors.

Features of the course of non-alcoholic liver steatosis in women of reproductive age and in menopause

In both groups of women with the clinical form of NASP, most of the studied laboratory parameters marked the transition to stage 1 obesity, leptin made it possible to differentiate almost all degrees of obesity, and the production of IL-6 and VEGF significantly increased at stages 2–3 of obesity.

Metabolically associated fatty liver disease – a disease of the 21st century: A review

Nonmedicamental therapies recommended for patients with MAFLD include weight loss, reduction of saturated fatty acid and fructose intake, and inclusion of adequate amounts of omega-3 polyunsaturated fatty acids and dietary fibre (psyllium) in the diet.

Evaluation of the Impact of Metabolic Syndrome on Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease.

  • H. KaniC. Demirtas Y. Yılmaz
  • Medicine
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • 2021
Greater age, a higher BMI, higher AST and a diagnosis of diabetes were more commonly associated with advanced fibrosis, however, DM was found to be the strongest predictive factor ofAdvanced fibrosis in the authors' cohort (OR: 2.495).



Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes

As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.

Association of Nonalcoholic Fatty Liver Disease With Components of Metabolic Syndrome According to Body Mass Index in Korean Adults

NAFLD was associated with risk for components of MetS, and the association was stronger in non-obese than in obese individuals, especially in women, Therefore, NAFLD should be considered a meaningful predictor of metabolic diseases in the non-OBese population.

Clinical, anthropometric, biochemical, and histological characteristics of nonobese nonalcoholic fatty liver disease patients of Bangladesh

Nonobese was 25.6 % among NAFLD patients of Bangladesh, and 53.1 % of nonobeseNAFLD cases were NASH, and NASH and fibrosis were similar in the obese andnonobese patients.

Anthropometric and Clinical Factors Associated with Mortality in Subjects with Nonalcoholic Fatty Liver Disease

Components of metabolic syndrome, and Mexican-American ethnicity are independently associated with nonalcoholic fatty liver disease and NAFLD is an independent predictors of liver-specific mortality in men and Whites.

Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011–2012

The multivariate logistic regression analysis revealed that ≥10 kg of weight gain since the age of 20 was significantly associated with NAFLD in non-obese subjects of both genders, and eating an evening meal within 2 h before going to bed 3 days or more per week and drinking <20 g of alcohol per day were negatively associated in non theobese females.

Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations.

The relative contribution of visceral and liver fat to insulin resistance is discussed, and recommendations for clinical evaluation of affected individuals is provided.

Prevalence and Risk Factors of Nonalcoholic Fatty Liver Disease in an Adult Population of Taiwan: Metabolic Significance of Nonalcoholic Fatty Liver Disease in Nonobese Adults

In subjects with NAFLD, the prevalence of elevated ALT in the presence of each metabolic risk factor, such as obesity, fasting plasma glucose, total cholesterol, triglyceride, and hypertriglyceridemia, did not differ from that of subjects with normal ALT levels.

Prevalence and Severity of Nonalcoholic Fatty Liver Disease in Non-Obese Patients: A Population Study Using Proton-Magnetic Resonance Spectroscopy

Non-obese patients with NAFLD do not have a higher risk of steatohepatitis or advanced fibrosis, and patients with risk factors ofadvanced fibrosis such as metabolic syndrome and PNPLA3 G allele carriage should be assessed for severeNAFLD.

The Severity of Histologic Liver Lesions Is Independent of Body Mass Index in Patients With Nonalcoholic Fatty Liver Disease

Almost 1 of 8 NAFLD patients coming to a Greek tertiary liver center has normal BMI, and on liver biopsy, normal BMI patients often have nonalcoholic steatohepatitis and histologic liver lesions of similar severity to the overweight or obese patients.