The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis

@article{Lu2018TheRB,
  title={The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis},
  author={Feng-Bin Lu and En-de Hu and Lanman Xu and Lu Chen and Jin-Lu Wu and Hui Li and Da-Zhi Chen and Yong-Ping Chen},
  journal={Expert Review of Gastroenterology \& Hepatology},
  year={2018},
  volume={12},
  pages={491 - 502}
}
ABSTRACT Introduction: A number of researches have explored the association between obesity and nonalcoholic fatty liver disease (NAFLD) liver function, histopathology, complications, genetic factors and prognosis, but the results were conflicting and inconclusive. Areas covered: In this meta-analysis, the liver function, histopathology, metabolic complications, patatin-like phospholipase domain-containing protein 3 (PNPLA3) genetic polymorphism and prognosis were compared between non-obese and… 

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Evaluation of the Impact of Metabolic Syndrome on Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease.

  • H. KaniC. Demirtas Y. Yılmaz
  • Medicine
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • 2021
Greater age, a higher BMI, higher AST and a diagnosis of diabetes were more commonly associated with advanced fibrosis, however, DM was found to be the strongest predictive factor ofAdvanced fibrosis in the authors' cohort (OR: 2.495).
...

References

SHOWING 1-10 OF 61 REFERENCES

Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes

As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.

Association of Nonalcoholic Fatty Liver Disease With Components of Metabolic Syndrome According to Body Mass Index in Korean Adults

NAFLD was associated with risk for components of MetS, and the association was stronger in non-obese than in obese individuals, especially in women, Therefore, NAFLD should be considered a meaningful predictor of metabolic diseases in the non-OBese population.

Clinical, anthropometric, biochemical, and histological characteristics of nonobese nonalcoholic fatty liver disease patients of Bangladesh

Nonobese was 25.6 % among NAFLD patients of Bangladesh, and 53.1 % of nonobeseNAFLD cases were NASH, and NASH and fibrosis were similar in the obese andnonobese patients.

Anthropometric and Clinical Factors Associated with Mortality in Subjects with Nonalcoholic Fatty Liver Disease

Components of metabolic syndrome, and Mexican-American ethnicity are independently associated with nonalcoholic fatty liver disease and NAFLD is an independent predictors of liver-specific mortality in men and Whites.

Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011–2012

The multivariate logistic regression analysis revealed that ≥10 kg of weight gain since the age of 20 was significantly associated with NAFLD in non-obese subjects of both genders, and eating an evening meal within 2 h before going to bed 3 days or more per week and drinking <20 g of alcohol per day were negatively associated in non theobese females.

Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations.

The relative contribution of visceral and liver fat to insulin resistance is discussed, and recommendations for clinical evaluation of affected individuals is provided.

Prevalence and Risk Factors of Nonalcoholic Fatty Liver Disease in an Adult Population of Taiwan: Metabolic Significance of Nonalcoholic Fatty Liver Disease in Nonobese Adults

In subjects with NAFLD, the prevalence of elevated ALT in the presence of each metabolic risk factor, such as obesity, fasting plasma glucose, total cholesterol, triglyceride, and hypertriglyceridemia, did not differ from that of subjects with normal ALT levels.

Prevalence and Severity of Nonalcoholic Fatty Liver Disease in Non-Obese Patients: A Population Study Using Proton-Magnetic Resonance Spectroscopy

Non-obese patients with NAFLD do not have a higher risk of steatohepatitis or advanced fibrosis, and patients with risk factors ofadvanced fibrosis such as metabolic syndrome and PNPLA3 G allele carriage should be assessed for severeNAFLD.

The Severity of Histologic Liver Lesions Is Independent of Body Mass Index in Patients With Nonalcoholic Fatty Liver Disease

Almost 1 of 8 NAFLD patients coming to a Greek tertiary liver center has normal BMI, and on liver biopsy, normal BMI patients often have nonalcoholic steatohepatitis and histologic liver lesions of similar severity to the overweight or obese patients.
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