The relationship between obesity and cognitive health and decline

  title={The relationship between obesity and cognitive health and decline},
  author={Louise Dye and Neil Bernard Boyle and Claire L Champ and Clare L. Lawton},
  journal={Proceedings of the Nutrition Society},
  pages={443 - 454}
  • L. Dye, N. Boyle, C. Lawton
  • Published 11 September 2017
  • Psychology, Medicine
  • Proceedings of the Nutrition Society
The relationship between obesity and cognitive impairment is important given the globally ageing population in whom cognitive decline and neurodegenerative disorders will carry grave individual, societal and financial burdens. This review examines the evidence for the link between obesity and cognitive function in terms of both the immediate effects on cognitive performance, and effects on the trajectory of cognitive ageing and likelihood of dementia. In mid-life, there is a strong association… 

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Examining the relationship between obesity and cognitive function: a systematic literature review.

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Obesity indices showed similar associations to cognitive function, and further work is needed to clarify the physiological mechanisms that link obesity to poor neurocognitive outcome.

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Findings support the hypothesis that the metabolic syndrome contributes to cognitive impairment in elders, but primarily in those with high level of inflammation.

Midlife overweight and obesity increase late-life dementia risk

Both overweight and obesity at midlife independently increase the risk of dementia, AD, and VaD, and genetic and early-life environmental factors may contribute to the midlife high adiposity–dementia association.

Body Mass Index and Decline of Cognitive Function

It is found that obesity was associated with lower risk of cognitive decline among mid- and old-age population and a slower decline of cognitive function was observed in obese individuals than those with normal weight, especially among women and those with low-normal K-MMSE score at baseline.

A diet based on multiple functional concepts improves cognitive performance in healthy subjects

Investigating effects on cognitive functions of a dietary regime combining multiple functional concepts potentially beneficial to risk markers associated with MetS indicates that diet characteristics may modulate cognitive performance.

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It is believed that the most plausible mechanism relating adiposity to AD is hyperinsulinemia, but it is unclear whether specific products of adipose tissue also have a role.

The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study.

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Promising strategies for the prevention of dementia.

Most promising, interventions of cognitive and physical activity improve cognitive performance and slow cognitive decline and future studies should continue to examine the implication of risk factor modification in controlled trials, with particular focus on whether several simultaneous interventions may have additive or multiplicative effects.