The relationship between neurotrophins and bipolar disorder.

  title={The relationship between neurotrophins and bipolar disorder.},
  author={Renrong Wu and Jinbo Fan and Jingping Zhao and Joseph R. Calabrese and Keming Gao},
  journal={Expert review of neurotherapeutics},
  volume={14 1},
Relationship between neurotrophins, especially brain-derived neurotrophic factor (BDNF) and bipolar disorder (BPD) has been widely investigated, but results have been inconsistent. BDNF polymorphism may be associated with the susceptibility to subtype BPD such as rapid cycling BPD or early onset BPD. Met allele carriers of Val66Met of BDNF gene had smaller gray matter (GM) in both patients and healthy controls, but bipolar patients carrying Met allele had better response to lithium treatment… CONTINUE READING

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