The relationship between neuronal survival and regeneration.

@article{Goldberg2000TheRB,
  title={The relationship between neuronal survival and regeneration.},
  author={Jeffrey L. Goldberg and Barbara A. Barres},
  journal={Annual review of neuroscience},
  year={2000},
  volume={23},
  pages={579-612}
}
The ability of peripheral nervous system (PNS) but not central nervous system (CNS) neurons to regenerate their axons is a striking peculiarity of higher vertebrates. Much research has focused on the inhibitory signals produced by CNS glia that thwart regenerating axons. Less attention has been paid to the injury-induced loss of trophic stimuli needed to promote the survival and regeneration of axotomized neurons. Could differences in the mechanisms that control CNS and PNS neuronal survival… CONTINUE READING

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