The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects.

@article{Wand2012TheRB,
  title={The relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects.},
  author={Gary Wand and Elise M Weerts and Hiroto Kuwabara and Dean F. Wong and Xiaoqiang Xu and Mary E McCaul},
  journal={Alcohol},
  year={2012},
  volume={46 6},
  pages={511-7}
}
The mu opioid receptor system is altered in alcohol dependent (AD) subjects. Cortisol responses to opioid receptor antagonists are assumed to impart information about opioid receptor activity. In the present study we examined naloxone-induced cortisol responses in 18 healthy control (HC) and 25 recently detoxified AD subjects and then correlated the cortisol response with mu opioid receptor availability across 15 brain regions using positron emission tomography (PET) and the mu opioid receptor… CONTINUE READING
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The Authors, Addiction Biology © 2012 Society for the Study of Addiction

  • Gary S. Wand
  • 2012

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