The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer.

@article{Rundle2000TheRB,
  title={The relationship between genetic damage from polycyclic aromatic hydrocarbons in breast tissue and breast cancer.},
  author={Andrew Rundle and Deliang Tang and Hanina Hibshoosh and Alison Estabrook and Freya R Schnabel and Wen-qing Cao and Surah Grumet and Frederica Perera},
  journal={Carcinogenesis},
  year={2000},
  volume={21 7},
  pages={1281-9}
}
A number of polycyclic aromatic hydrocarbons (PAH) are widespread environmental contaminants that cause mammary cancer experimentally. We investigated whether exposure and susceptibility to PAH, as measured by PAH-DNA adducts in breast tissue, are associated with human breast cancer. We carried out a hospital-based case-control study using immunohistochemical methods to analyze PAH-DNA adducts in tumor and nontumor breast tissue from cases and benign breast tissue from controls. The subjects… CONTINUE READING
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